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Nucleophilic Acyl Substitution Reactivity Solutions Library

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Nucleophilic Acyl Substitution Reactivity

Q. Rank the following carbonyl-containing compounds in order of reactivity towards nucleophile attack. 

Solved • Jul 30, 2018

Nucleophilic Acyl Substitution Reactivity

Q. Which of the following carboxylic acid derivative is most reactive towards nucleophilic acyl substitution?a. IIIb. Ic. IVd. II 

Solved • Jul 24, 2018

Nucleophilic Acyl Substitution Reactivity

Q. Rank the following carbonyl-containing compounds in order to reactivity towards nucleophilic acyl substitution.  Butyl acetate, acetic propionic an...

Solved • Jul 24, 2018

Nucleophilic Acyl Substitution Reactivity

Q. Draw the major product of the following reaction. Draw the molecule on the canvas by choosing buttons by default.

Solved • May 18, 2018

Nucleophilic Acyl Substitution Reactivity

Q. Which of the following methods cannot be used to make the compound hexanamide shown below?

Solved • Jun 2, 2017

Nucleophilic Acyl Substitution Reactivity

Q. Complete the following reaction supplying the missing product and showing correct regio- and stereochemistry where applicable. If a racemic or dias...

Solved • May 25, 2017

Nucleophilic Acyl Substitution Reactivity

Q. Rank the following molecules in increasing order of reactivity to nucleophilic acyl substitution.

Solved • May 9, 2017

Nucleophilic Acyl Substitution Reactivity

Q. Which of the following is the correct order of decreasing leaving group ability in nucleophilic acyl substitutions (better leaving group > worse...

Solved • Jan 12, 2017

Nucleophilic Acyl Substitution Reactivity

Q. Rank the following carboxylic derivatives indereasing order (most to least) order of reactivity towards nuclephilic substitution. a IV>II>I&...

Solved • Jan 10, 2017

Nucleophilic Acyl Substitution Reactivity

Q. Rank the following carboxylic acid derivatives with respect to reactivity with a nucleophile. Write a 1 under the most reactive, and a 4 under the ...

Solved • Jan 4, 2017

Nucleophilic Acyl Substitution Reactivity

Q. You are going to have to think about this one! The following pKa values will help in your analysis:

Solved • Jan 3, 2017

Nucleophilic Acyl Substitution Reactivity

Q. Predict the major product for the following reaction paying attention to the regio- and stereochemistry.

Solved • Sep 27, 2016

Nucleophilic Acyl Substitution Reactivity

Q. Suggest a synthetic scheme to complete the following transformation. Show all the reagents and the intermediates that are formed. There is no need ...

Solved • May 17, 2016

Nucleophilic Acyl Substitution Reactivity

Q. Which reaction sequence would best accomplish this transformation? 

Solved • May 8, 2016

Nucleophilic Acyl Substitution Reactivity

Q. Draw the organic product(s) for the following reaction. Indicate stereochemistry where appropriate. Assume an aqueous workup, when necessary. A rea...

Solved • May 4, 2016

Nucleophilic Acyl Substitution Reactivity

Q. Show how you would accomplish the following conversion.

Solved • Apr 5, 2016

Nucleophilic Acyl Substitution Reactivity

Q. Draw the organic product of the following reaction. If no reaction occurs, write "No Reaction." Indicate stereochemistry where appropriate. Assume ...

Solved • Apr 5, 2016

Nucleophilic Acyl Substitution Reactivity

Q. The relative reactivity of acyl compounds toward nucleophilic acyl addition- elimination is:a) Amide > ester > acid anhydride >  acyl chlo...

Solved • Apr 5, 2016

Nucleophilic Acyl Substitution Reactivity

Q. Place the following molecules in order of their reactivity under base-catalyzed nucleophilic addition-elimination conditions. Label the most reacti...

Solved • Mar 30, 2016

Nucleophilic Acyl Substitution Reactivity

Q. Rate the following compunds from the most reactive (assign number 1) to the least reactive (assign number 3). 

Solved • Feb 24, 2016