Problem: Which of the following carboxylic acid derivative is most reactive towards nucleophilic acyl substitution?a. IIIb. Ic. IVd. II 

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Problem Details

Which of the following carboxylic acid derivative is most reactive towards nucleophilic acyl substitution?

a. III

b. I

c. IV

d. II 

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Based on our data, we think this problem is relevant for Professor Houjeiry's class at CLEMSON.