🤓 Based on our data, we think this question is relevant for Professor Lever's class at MIZZOU.
Rank the SN1 reaction rates for the following compounds:
iodomethane, 2-iodo-2-methylhexane, 1-iodo-2-methylhexane, 3-iodo-2-methylhexane
We’re being asked to rank the reaction rates of each compound for an SN1 reaction.
Recall that the SN1 reaction occurs in two steps:
(1) carbocation formation – the carbon-leaving group bond is broken
(2) nucleophilic attack – the nucleophile donates its electron to the positively-charged carbon (electrophile)
Hyperconjugation from additional R-groups stabilizes the carbocation. This means a more substituted alkyl halide will have a faster reaction rate.