Ch. 1 - A Review of General ChemistryWorksheetSee all chapters
All Chapters
Ch. 1 - A Review of General Chemistry
Ch. 2 - Molecular Representations
Ch. 3 - Acids and Bases
Ch. 4 - Alkanes and Cycloalkanes
Ch. 5 - Chirality
Ch. 6 - Thermodynamics and Kinetics
Ch. 7 - Substitution Reactions
Ch. 8 - Elimination Reactions
Ch. 9 - Alkenes and Alkynes
Ch. 10 - Addition Reactions
Ch. 11 - Radical Reactions
Ch. 12 - Alcohols, Ethers, Epoxides and Thiols
Ch. 13 - Alcohols and Carbonyl Compounds
Ch. 14 - Synthetic Techniques
Ch. 15 - Analytical Techniques: IR, NMR, Mass Spect
Ch. 16 - Conjugated Systems
Ch. 17 - Aromaticity
Ch. 18 - Reactions of Aromatics: EAS and Beyond
Ch. 19 - Aldehydes and Ketones: Nucleophilic Addition
Ch. 20 - Carboxylic Acid Derivatives: NAS
Ch. 21 - Enolate Chemistry: Reactions at the Alpha-Carbon
Ch. 22 - Condensation Chemistry
Ch. 23 - Amines
Ch. 24 - Carbohydrates
Ch. 25 - Phenols
Ch. 26 - Amino Acids, Peptides, and Proteins

Solution: Determine the index of hydrogen deficiency (degrees of unsaturation) for the following molecule.Antipsychotic - Haloperidol = C21H23NO2ClF

Solution: Determine the index of hydrogen deficiency (degrees of unsaturation) for the following molecule.Antipsychotic - Haloperidol = C21H23NO2ClF

Problem

Determine the index of hydrogen deficiency (degrees of unsaturation) for the following molecule.

Antipsychotic - Haloperidol = C21H23NO2ClF

Solution

We’re being asked to determine the index of hydrogen deficiency (IHD) for haloperidol, C21H23NO2ClF.


Recall that the degrees of unsaturation or index of hydrogen deficiency (IHD) tell us how many hydrogens are missing in a structure.


For a given molecular formula, the IHD is calculated using:


IHD=[2n+2]-H2


where n = number of carbons and H is:

+1 for hydrogen (H) or halogens (X)

0 for oxygen (O)

–1 for nitrogen (N)


View the complete written solution...