Problem: Determine the index of hydrogen deficiency (degrees of unsaturation) for the following molecule.Antipsychotic - Haloperidol = C21H23NO2ClF

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We’re being asked to determine the index of hydrogen deficiency (IHD) for haloperidol, C21H23NO2ClF.


Recall that the degrees of unsaturation or index of hydrogen deficiency (IHD) tell us how many hydrogens are missing in a structure.


For a given molecular formula, the IHD is calculated using:


IHD=[2n+2]-H2


where n = number of carbons and H is:

+1 for hydrogen (H) or halogens (X)

0 for oxygen (O)

–1 for nitrogen (N)


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Problem Details

Determine the index of hydrogen deficiency (degrees of unsaturation) for the following molecule.

Antipsychotic - Haloperidol = C21H23NO2ClF

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