For a unimolecular nucleophilic substitution (________) reactions, bond breaking and bond formation occur _______, ________ is/are involved in the transition state of the rate-determinining step. However, for biomolecular nucleophilic substitution (_______) reactions, bond breaking and bond formation occur _______. A bimolecular reaction is one in which _______ is/are involved in the transition state of the rate determining step.
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