Ch. 4 - Alkanes and CycloalkanesWorksheetSee all chapters
All Chapters
Ch. 1 - A Review of General Chemistry
Ch. 2 - Molecular Representations
Ch. 3 - Acids and Bases
Ch. 4 - Alkanes and Cycloalkanes
Ch. 5 - Chirality
Ch. 6 - Thermodynamics and Kinetics
Ch. 7 - Substitution Reactions
Ch. 8 - Elimination Reactions
Ch. 9 - Alkenes and Alkynes
Ch. 10 - Addition Reactions
Ch. 11 - Radical Reactions
Ch. 12 - Alcohols, Ethers, Epoxides and Thiols
Ch. 13 - Alcohols and Carbonyl Compounds
Ch. 14 - Synthetic Techniques
Ch. 15 - Analytical Techniques: IR, NMR, Mass Spect
Ch. 16 - Conjugated Systems
Ch. 17 - Aromaticity
Ch. 18 - Reactions of Aromatics: EAS and Beyond
Ch. 19 - Aldehydes and Ketones: Nucleophilic Addition
Ch. 20 - Carboxylic Acid Derivatives: NAS
Ch. 21 - Enolate Chemistry: Reactions at the Alpha-Carbon
Ch. 22 - Condensation Chemistry
Ch. 23 - Amines
Ch. 24 - Carbohydrates
Ch. 25 - Phenols
Ch. 26 - Amino Acids, Peptides, and Proteins

Now that we know how to calculate the difference in flip energy, we can plug that information into the famous Equilibrium Constant equation to determine exact Ke of the reaction. 

Concept #1: Calculate the difference in Gibbs free energy between the alternative chair conformations of trans-4-iodo-1-cyclohexanol.

Gas Constant correct number: 8.314


Once we have the Ke of the equilibria, we can solve for x, which will be the percentage of my most favored chair.   

Practice: Estimate the equilibrium composition of the chair conformers of cis-1,3-diethylcyclohexane at room temperature.

Did you remember to use the correct Gas Constant number?! (8.314)

Practice: Estimate the equilibrium composition of the chair conformers of trans-1-methyl-3-phenylcyclohexane at room temperature.

Note: The correct value for methyl should be 7.6, not 4.2


With that, the correct answer should be closer to 88% / 12% for the percentage of both chairs using the correct value for R (8.314). Hope that makes sense!