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The binding of oxygen by hemoglobin (Hb), giving oxyhemoglobin (HbO2), is partially regulated by the concentration of H3O+ and dissolved CO2 in the blood. Although the equilibrium is complicated, it can be summarized as
HbO2(aq) + H3 O+(aq) + CO2(g) ⇌ CO2 −Hb−H+ + O2(g) + H2 O(l)
(b) Explain why the production of lactic acid and CO 2 in a muscle during exertion stimulates release of O2 from the oxyhemoglobin in the blood passing through the muscle.
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