Cell Cycle Regulation

Normal cells are: a. anchorage dependent, density independent, division limited b. density dependent, anchorage independent, division not limited c. density dependent, anchorage dependent, division limited

By ignoring a checkpoint in the cell cycle, a cancer cell may:  a. Divide after mutations are fixed b. Divide before its DNA is completely replicated c. Condense its chromosomes before mitosis d. Align chromosomes on the equator of the cell during metaphase e. Pull chromosomes apart during anaphase

In order for a cell to become cancerous, oncogenes must be ___ and tumor suppressors ___. a. Inactivated, activatedb. Both activatedc. Both inactivatedd. Activated, inactivate

Checkpoints within the cell cycle:a. are located within interphase and allow entry to G 0b. are located within G1, S and G2c. are located within G1, M and G2d. are located within G1, M, S and G2

Replication of DNA takes place during the G1 phase of interphase.a. Trueb. False

During the cell cycle there are several checkpoints that ensure that the cell cycle is proceeding correctly. a. Trueb. False

An abnormal mass of tissue is a tumor. a. Trueb. False

If a cancer metastasizes, its cells travel through the blood stream and colonize other areas of the body.  a. True b. False

What are Check points in cell cycle?

What is cancer, why does it occur, and how do its properties evolve in humans undergoing chemotherapy?

What happens if mitosis occurs in an uncontrolled manner in the body?

In addition to Cdk1, mitosis is controlled by other kinases including polo-like kinases (PLKs). PLKs participate in mitosis by being recruited to the mitotic spindle and activated by:A. direct phosphorylation of PLKs by Cdk1B. autophosphorylationC. binding to a phosphorylated consensus sequence called polo boxes.D. binding to phosphorylated Cdk1.E. binding to cyclin.

After a protein called XrB binds to its receptor on the surface of a cell, a signal transduction pathway leads to inhibition of the cell cycle. A mutant cell line is discovered in which one of the relay proteins in the signal transduction pathway isabsent. What would be the outcome for the mutant cells?A. the cell never dividesB. the cells only divide when XrB is presentC. the cells only divide when XrB is absentD. the cells divide whether XrB is present or absent

Which one of the following statements regarding the S cyclin-CDK complex is TRUE?A. It is responsible for the phosphorylation of nuclear proteins.B. It regulates the expression of histone proteins.C. It ensures that DNA is not replicated multiple times.D. It is responsible for the degradation of nuclear membranes.E. It is regulated solely by the action of p53.

Which of the following cell cycle control system proteins are regulated by phosphorylation?A. cyclinsB. CdksC. Cdk inhibitorsD. cyclins and Cdks

What are the two proteins that regulate cell cycle?