Problem: Given the following equilibrium, at what pH would the molecule most likely be in a zwitterionic form?H3N+-CH2-COOH ⇌ H3N+-CH2-COO- ⇌ H2N-CH2-COO-                          pKa1: 2.4                     pKa2: 9.6A. 1.2B. 2.4C. 6.7D. 10.5E. 13.7

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Amino acids, peptides, and proteins can have different net charges, depending on the pH and the amount of ionizable groups present in the molecule. The given molecule is glycine, which only has two ionizable groups.

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Problem Details

Given the following equilibrium, at what pH would the molecule most likely be in a zwitterionic form?

H3N+-CH2-COOH ⇌ H3N+-CH2-COO- ⇌ H2N-CH2-COO-

                          pKa1: 2.4                     pKa2: 9.6

A. 1.2

B. 2.4

C. 6.7

D. 10.5

E. 13.7

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