Ch.16 - DNA SynthesisWorksheetSee all chapters
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Solution: Which of the following enzymes in base pair excision repair is NOT required to repair depurinated nucleotides?A. DNA polymeraseB. LigaseC. GlycosylaseD. Endonuclease

Problem

Which of the following enzymes in base pair excision repair is NOT required to repair depurinated nucleotides?

A. DNA polymerase

B. Ligase

C. Glycosylase

D. Endonuclease

Solution

Depurination is the spontaneous hydrolysis of the N-glycosyl linkages to the deoxyribose in the DNA. This is a quite common alteration to the DNA sequences which happens everyday. Along with deamintaion, these processes are the two most frequent source of DNA damage through spontaneous chemical reactions. One possible mechanism to repair its damage is through base pair excision.

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