DNA replication is basically the synthesis of a polynucleotide strand that is complementary to the template strand in the 5' to 3' direction. This polynucleotide synthesis happens in a fast base-pairing process with very high integrity conservation. This low error rate means that an error can only be seen once in every 104 to 106 bases. One reason for this low error rate is the proofreading mechanism of the DNA polymerase: as the bases are paired, any possible errors are detected by the replication complex. This greatly reduces the number of errors occurring in the replication process.
Which DNA repair mechanism do you expect to fix errors that escaped repair by proofreading?
A. the mismatch repair system
B. base-excision repair
C. nucleotide-excision repair
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