# Problem: A man homozygous for sickle cell disease (an autosomal recessive disease, i.e. not sex linked) who has normal vision marries a woman heterozygous for sickle cell disease who is colorblind (a recessive X-linked condition). What is the chance that a child (of either sex) born to them will have both sickle cell disease and be colorblind.A. 0B. 1/2C. 3/8D. 1/4E. 1/8

###### FREE Expert Solution

From the given problem, if we let A/a be the gene for sickle cell disease and the superscript b in the X chromosomes indicate the recessive colorblind allele, we can deduce that the man would have the genotype aaX+Y, while his wife would have the genotype AaXbXb.

###### Problem Details

A man homozygous for sickle cell disease (an autosomal recessive disease, i.e. not sex linked) who has normal vision marries a woman heterozygous for sickle cell disease who is colorblind (a recessive X-linked condition). What is the chance that a child (of either sex) born to them will have both sickle cell disease and be colorblind.

A. 0

B. 1/2

C. 3/8

D. 1/4

E. 1/8