Problem: What even triggers the release of histamine from mast cells and basophils in an allergic response?

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The thing that you are allergic to, first sends chemical signal to your nose, mouth, skin etc. 

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What even triggers the release of histamine from mast cells and basophils in an allergic response?

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Our tutors have indicated that to solve this problem you will need to apply the Innate Immunity concept. You can view video lessons to learn Innate Immunity. Or if you need more Innate Immunity practice, you can also practice Innate Immunity practice problems.